COX-2 inhibitors (coxibs)
COX-2 inhibitors, or coxibs, are anti-inflammatory painkillers that mainly block the COX-2 enzyme. They are used for pain and swelling in arthritis and similar conditions. They can still cause stomach ulcers, raise blood pressure and increase the risk of heart attack and stroke, so they are used at the lowest dose for the shortest time.
Pharmacist review in progress. This page is based on the sources listed below and is being checked by our registered pharmacist.
How do COX-2 inhibitors (coxibs) work?
Coxibs mainly block COX-2, an enzyme that makes the prostaglandins causing pain and swelling. They act less on COX-1, which helps protect the stomach lining, so they may upset the stomach less than older NSAIDs.
Active ingredients of this type
These active ingredients belong to COX-2 inhibitors (coxibs). They are listed A to Z.
- Etoricoxib: Etoricoxib is a prescription pain and inflammation medicine of the COX-2 inhibitor (coxib) group.
Common questions
How is a coxib different from other NSAIDs?
A coxib mainly blocks COX-2, so it may upset the stomach less than some older NSAIDs, but it can still cause ulcers and bleeding. It also carries heart and blood pressure risks. It is not stronger or better for everyone.
Are coxibs prescription medicines?
Yes, they are prescribed by a doctor. They should not be started, stopped or changed without the doctor's advice, and should not be combined with other NSAIDs unless a doctor advises.
Can coxibs affect the heart?
Yes. Medicines of this group may raise the risk of heart attack and stroke, and can raise blood pressure. Tell your doctor about heart disease, stroke, high blood pressure, diabetes or smoking before taking one.
Sources
- Arcoxia 90 mg film-coated tablets: Summary of Product Characteristics. electronic medicines compendium (emc), UK
- ATC/DDD Index: M01AH05 Etoricoxib. WHO Collaborating Centre for Drug Statistics Methodology