Gabapentinoids: What They Do, Medicines
Gabapentinoids are prescription medicines used to treat nerve pain and some types of seizures. The two common ones are gabapentin and pregabalin, and pregabalin is also used for generalised anxiety. They can cause drowsiness and dizziness, and some people become dependent on them. They should not be stopped suddenly without a doctor's advice.
Pharmacist review in progress. This page is based on the sources listed below and is being checked by our registered pharmacist.
How do Gabapentinoids work?
Gabapentinoids bind to a protein on nerve cells that controls the release of chemical messengers. This calms over-active nerve signals, which can reduce nerve pain and seizures.
Active ingredients of this type
These active ingredients belong to Gabapentinoids. They are listed A to Z.
- Gabapentin: Gabapentin is a prescription medicine used to treat some types of seizures in epilepsy and to relieve nerve pain.
- Pregabalin: Pregabalin is a prescription medicine used to treat nerve pain, some types of seizures and generalised anxiety in adults.
Common questions
Can gabapentinoids cause dependence?
Yes, in some people. Withdrawal symptoms such as anxiety, trouble sleeping, nausea, pain and sweating can follow sudden stopping. Tell your doctor if you have ever misused a medicine, and never stop or change the dose on your own.
Why do these medicines cause drowsiness?
They act on nerve signalling in the brain, so sleepiness and dizziness are common, especially at the start or after a dose change. Alcohol and strong painkillers can add to this. Avoid driving until you know how they affect you.
Are gabapentin and pregabalin the same?
They belong to the same group and work in a similar way, but they are different medicines with different strengths and uses. One should not be swapped for the other without a doctor's advice.
Sources
- Gabapentin (side effects, how to take, pregnancy, other medicines, who can take). NHS (UK)
- Pregabalin (side effects, how to take, pregnancy, other medicines, who can take). NHS (UK)
- National Formulary of India. Indian Pharmacopoeia Commission