Tricyclic antidepressants
Tricyclic antidepressants are prescription medicines, named for their three-ring chemical shape. They are used mainly to treat depression. Amitriptyline is a well-known example. They can cause drowsiness, dry mouth and heart rhythm effects, and are not stopped suddenly.
Pharmacist review in progress. This page is based on the sources listed below and is being checked by our registered pharmacist.
How do Tricyclic antidepressants work?
Tricyclic antidepressants are thought to block nerve cells from taking back the chemical messengers serotonin and noradrenaline, so more of them stay available in the brain. Over some weeks this is linked with an improvement in mood.
Active ingredients of this type
These active ingredients belong to Tricyclic antidepressants. They are listed A to Z.
- Amitriptyline: Amitriptyline is a prescription antidepressant of the tricyclic group, used to relieve the symptoms of depression.
Common questions
Why do antidepressants carry a warning for young people?
Labels warn that antidepressants can increase suicidal thoughts and behaviour in children, teenagers and young adults, mostly early in treatment or after a dose change. Family or carers should watch for new or worsening mood changes and contact the doctor promptly.
Can I stop a tricyclic antidepressant suddenly?
No. Stopping suddenly can cause nausea, headache and a feeling of being unwell. A doctor reduces the dose gradually. Do not stop on your own, even if you feel better.
Are tricyclics dangerous in overdose?
Yes. An overdose of a tricyclic antidepressant can seriously affect the heart and can be fatal. Keep tablets out of reach of children, and call 112 or go to the nearest hospital if too much has been taken.
Sources
- Amitriptyline hydrochloride tablet, film coated: prescribing information (Sun Pharmaceutical Industries). DailyMed, US National Library of Medicine
- Amitriptyline. MedlinePlus, US National Library of Medicine