DoseFacts

Paracetamol: Uses, How It Works, Medicines

Also in: हिन्दी தமிழ் मराठी తెలుగు ಕನ್ನಡ বাংলা ગુજરાતી മലയാളം

Paracetamol (also called acetaminophen) is a medicine used to bring down fever and to relieve mild to moderate pain. It is used for headache, body ache, toothache, period pain and fever with colds, flu and viral infections. It eases symptoms but does not treat the infection or condition causing them.

Also known as: Acetaminophen, APAP, Paracetamol IP, Paracetamol tablet, Fever tablet (bukhar ki goli)

Medically reviewed by: V.Ragha Sai Pravallika, B.Pharm · Reg. No. TG081267 (Telangana Pharmacy Council)

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Paracetamol at a glance. Used for: Fever, Headache, Body ache, Toothache, Period pain. Ask a doctor first: Liver disease, Regular or heavy drinking, Weight under 50 kg or poor eating, Serious kidney disease, Pregnancy or breastfeeding, Past allergy to paracetamol, Giving it to a child. Get medical help quickly for: Swelling of the face, lips or throat, Difficulty breathing, Blistering or peeling skin, Yellow skin or eyes, or dark urine, Unusual bruising or bleeding, Fever lasting more than 3 days. Taking too much: Many cold and flu medicines also contain paracetamol, so check labels to avoid a double dose. Too much is an emergency even if you feel well: call 112. Dose: follow the label or your doctor's advice.

How does Paracetamol work?

Paracetamol works mainly in the brain and spinal cord, where it reduces prostaglandins, chemical messengers that raise body temperature and make nerves more sensitive to pain; unlike NSAIDs such as ibuprofen, it does little to reduce swelling. After it is swallowed, it is absorbed from the gut into the blood, which carries it around the whole body, and the liver later breaks it down. Above the daily maximum the liver cannot keep up, and a harmful by-product builds up that can damage liver cells.

How to take Paracetamol

Follow the label or your doctor's advice. For adults, labels commonly allow up to 4 g (4,000 mg) in 24 hours from all medicines combined, with at least 4 hours between doses. Children need a dose based on their weight from a doctor, and fever lasting more than 3 days needs a doctor's review.

Side effects of Paracetamol

Side effects are uncommon when paracetamol is taken at the right dose. The main danger is liver damage from taking too much.

Uncommon or mild

  • Feeling sick (nausea)
  • A mild skin rash

Rare but serious: get medical help

  • Signs of a severe allergic reaction: swelling of the face, lips or throat, difficulty breathing, or a sudden widespread rash
  • Red skin with blisters or peeling, which can happen even with first-time use. Stop the medicine and get medical help immediately
  • Yellowing of the skin or eyes, dark urine, or pain in the upper right side of the tummy, which can be signs of liver damage
  • Unusual bruising, bleeding or frequent infections, which are very rare signs of a blood disorder

Who should be careful

Most people can take paracetamol safely, but some need to check with a doctor first because they are more at risk of liver damage or need a different dose.

When the label says not to use it

  • Allergy to paracetamol or any ingredient of the tablet
  • Already taking another medicine that contains paracetamol
  • Liver disease, or a history of liver problems
  • Drinking alcohol regularly or heavily
  • Body weight under 50 kg, malnutrition, or not eating for a long time
  • Serious kidney disease
  • Pregnancy or breastfeeding: paracetamol is commonly used when needed, but ask your doctor and use the lowest dose for the shortest time
  • Past allergic reaction to paracetamol
  • Children: use only a children's form at the dose a doctor gives

Medicines and things that interact with Paracetamol

Paracetamol has few interactions, but a few medicines and habits change how safe or effective it is. Tell your doctor or pharmacist about everything you take.

  • Other medicines containing paracetamol, including many cold and flu products and some combination painkillers: risk of overdose
  • Warfarin and similar blood thinners: regular paracetamol use can increase their effect and the risk of bleeding
  • Medicines for epilepsy such as carbamazepine, phenytoin and phenobarbital, and the TB medicines rifampicin and isoniazid: may increase the risk of liver damage
  • Metoclopramide and domperidone (for nausea): can make paracetamol work faster
  • Cholestyramine (for cholesterol): reduces how much paracetamol is absorbed if taken at the same time
  • Flucloxacillin (an antibiotic): taking both can rarely cause a serious build-up of acid in the blood, mainly in people who are very ill
  • Alcohol: regular or heavy drinking increases the risk of liver damage

If someone takes too much

Taking too much paracetamol is a medical emergency, even if the person feels well. Serious liver damage can develop over the next 1 to 3 days with few or no early symptoms. Treatment works best when started within 8 hours, so call 112 or go to the nearest hospital immediately and take the medicine pack with you.

In India

Price cap, essential-medicine listing and legal status in India, taken from government notifications.

Price cap (NPPA)

  • 500 mg tablet₹0.93 per tablet
  • 650 mg tablet₹2.05 per tablet
  • 120 mg/5 mL oral liquid₹0.62 per mL
  • 125 mg/5 mL oral liquid₹0.38 per mL
  • 250 mg/5 mL oral liquid₹0.68 per mL
  • 80 mg suppository₹6.82 per suppository
  • 170 mg suppository₹8.14 per suppository

Ceiling price fixed by the National Pharmaceutical Pricing Authority (NPPA), excluding GST, in force from 1 April 2026 (S.O. 1575(E) dated 25 March 2026). The printed pack price (MRP) may not be higher than this price plus GST.

Essential medicine (NLEM)

Listed in the National List of Essential Medicines (NLEM) 2022: 500 mg tablet, 650 mg tablet, 120 mg/5 mL oral liquid, 125 mg/5 mL oral liquid, 250 mg/5 mL oral liquid, 150 mg/mL injection, 80 mg suppository, 170 mg suppository.

Regulatory status in India

Approved for sale in India. Single-ingredient paracetamol is not on the CDSCO list of banned medicines. Some fixed-dose combinations that pair paracetamol with other medicines were banned in August 2024, so check the ingredient list on the pack.

Type of medicine

Paracetamol belongs to this type of medicine.

Medicines that contain Paracetamol

These medicines sold in India contain Paracetamol. They are listed A to Z, not ranked.

What is Paracetamol used for?

Medicines that contain Paracetamol are used for these conditions.

Common questions

Is paracetamol the same as acetaminophen?

Yes. Paracetamol is the name used in India and the UK, and acetaminophen is the name used in the US. Many brands contain it, alone or mixed with other medicines, so check labels before taking two products together, as this can double the dose.

How much paracetamol can be taken in a day?

Follow the label or your doctor's advice. For adults, labels commonly give a maximum of 4 g in 24 hours from all medicines combined, with at least 4 hours between doses. Lower limits may apply to people with liver problems, low body weight or regular alcohol use.

Is paracetamol used for fever in dengue?

Paracetamol is the medicine usually used to control fever and pain in dengue. Painkillers such as ibuprofen and aspirin are avoided because they can increase the risk of bleeding. Dengue needs a doctor's care; paracetamol only eases the symptoms.

Is Dolo 650 the same as paracetamol?

Dolo 650 is a brand name. Its tablet contains paracetamol alone, 650 mg per tablet, so the medicine is paracetamol. Other brands such as Calpol and Crocin also sell paracetamol, but some versions add other ingredients, so read the ingredient list and strength on the pack.

What is the difference between paracetamol and ibuprofen?

Both ease pain and fever. Paracetamol works mainly in the brain and does little for swelling. Ibuprofen is an NSAID that also reduces inflammation but can irritate the stomach and affect the kidneys. Which one suits a person depends on their health, so ask a doctor or pharmacist.

Can paracetamol be taken on an empty stomach?

Yes. Paracetamol tablets can be taken with or without food. Food may slow how quickly it starts to work, but it does not change how well it works. Swallow tablets with water and follow the gap between doses given on the label.

Is paracetamol safe in pregnancy or while breastfeeding?

Paracetamol is commonly used in pregnancy when medicine is needed, at the lowest dose for the shortest time. It is also usually considered suitable while breastfeeding. Ask your doctor about any medicine used in pregnancy, especially if fever or pain lasts more than a day or two.

What is paracetamol called in Hindi, and is 'bukhar ki goli' paracetamol?

The name stays the same in Hindi, written पैरासिटामोल. People often say 'bukhar ki goli' (fever tablet) for brands such as Dolo or Crocin, but that describes a use, not one medicine. Check the label to see what a tablet actually contains.

Can paracetamol damage the liver or kidneys?

At the doses on the label, paracetamol rarely harms the liver or kidneys. Taking more than the daily maximum, even a little extra over several days, can cause serious liver damage. People with liver or serious kidney disease, low body weight or heavy drinking should ask a doctor first, as a lower limit may apply.

Can I drink alcohol while taking paracetamol?

NHS guidance says moderate drinking is usually fine with normal doses of paracetamol. Regular heavy drinking or binge drinking raises the risk of liver damage, and a lower daily limit may apply. If you drink a lot or often, ask a doctor or pharmacist before taking it.

How many hours should there be between paracetamol doses?

Follow the label or your doctor's advice. For adults, labels commonly say to leave at least 4 hours between doses and to take no more than 4 doses in 24 hours. Children's syrups and drops have their own gap and limit printed on the pack.

Can paracetamol be taken with cold and flu medicines?

Check every label first. Many cold and flu products, combination painkillers and some fever syrups already contain paracetamol, sometimes listed as acetaminophen. Taking two of them together can push the total above the daily maximum without you noticing. Count paracetamol from all products together, and ask a pharmacist if unsure.

What if a fever does not come down after paracetamol?

Paracetamol lowers temperature but does not treat the cause of a fever. See a doctor if fever lasts more than 3 days, or comes with a rash, bleeding, severe headache, stiff neck, breathing trouble, confusion or repeated vomiting. Do not take more than the label allows to bring it down.

How long does paracetamol take to work?

Paracetamol taken by mouth usually starts to ease pain or fever within about an hour, and the effect of a dose lasts around 4 to 6 hours. This is why labels leave at least 4 hours between doses. Soluble tablets and syrups may act a little faster than standard tablets.

Is paracetamol an antibiotic or an NSAID?

Neither. Paracetamol relieves pain and lowers fever, but it does not kill bacteria, so it does not treat infections. It is usually not grouped with NSAIDs such as ibuprofen, because it has little effect on inflammation.

Is paracetamol banned in India?

No. Single-ingredient paracetamol is approved for sale in India and is not on the CDSCO list of banned medicines. Some fixed-dose combinations that pair paracetamol with other medicines were banned in August 2024, so check the ingredient list on any combination product.

Sources

  1. Acetaminophen. StatPearls, National Center for Biotechnology Information (NCBI), US National Library of Medicine
  2. Paracetamol for adults. NHS (UK)
  3. Dengue and severe dengue (fact sheet). World Health Organization
  4. Banned drugs, fixed-dose combinations. Central Drugs Standard Control Organisation (CDSCO), India
  5. National Formulary of India. Indian Pharmacopoeia Commission
  6. Paracetamol 500 mg Tablets (Zentiva): Summary of Product Characteristics. electronic medicines compendium (emc), UK
  7. Paracetamol 500mg Tablets (Flamingo Pharma): Summary of Product Characteristics. electronic medicines compendium (emc), UK
  8. S.O. 1575(E), 25 March 2026: revision of ceiling prices of 767 scheduled formulations under NLEM 2022 (annual WPI revision). National Pharmaceutical Pricing Authority (NPPA), Government of India
  9. National List of Essential Medicines 2022 (section 2.1.5, Paracetamol). Ministry of Health and Family Welfare, Government of India (copy hosted by CDSCO)