DoseFacts

Azithromycin: Uses, How It Works, Medicines

Also in: हिन्दी தமிழ் मराठी తెలుగు ಕನ್ನಡ বাংলা ગુજરાતી മലയാളം

Azithromycin is a macrolide antibiotic used to treat certain bacterial infections. These include infections of the chest, sinuses, throat, ears and skin, and some sexually transmitted infections such as chlamydia. It works only against bacteria, so it does not help colds, flu or other viral infections. In India it is a prescription medicine.

Also known as: Azithromycin dihydrate, Azithromycine, Azithromycin tablet, Azithromycin 500 mg, Azithromycin antibiotic

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Azithromycin at a glance. Used for: Chest infections, Sinus infections, Throat and ear infections, Skin infections, Some sexually transmitted infections. Ask a doctor first: Allergy to macrolide antibiotics, Heart rhythm problems, Liver disease, Severe kidney disease, Myasthenia gravis, Pregnancy or breastfeeding. Get medical help quickly for: Swelling of the face, lips or throat, Difficulty breathing, Fast or irregular heartbeat, or fainting, Blistering or peeling skin, Yellow skin or eyes, or dark urine, Severe or bloody diarrhoea. Taking too much: One extra dose by mistake is unlikely to cause serious harm. If someone takes much more or feels unwell, call 112 or go to the nearest hospital. Dose: follow the label or your doctor's advice.

How does Azithromycin work?

Azithromycin binds to the larger (50S) part of the bacterial ribosome and stops bacteria from making the proteins they need to grow and multiply. It builds up in tissues such as the lungs, tonsils and skin and leaves the body slowly, so it is usually taken once a day and courses are often short.

How to take Azithromycin

Follow the label or your doctor's advice. Azithromycin is usually taken once a day, and courses are often short, such as 3 to 5 days, but the dose and the number of days depend on the infection. Take the full course your doctor prescribed.

Side effects of Azithromycin

Most people take azithromycin without serious problems. Stomach upset is the most common side effect, and serious reactions are rare.

Uncommon or mild

  • Diarrhoea
  • Feeling sick (nausea) or being sick (vomiting)
  • Stomach pain
  • Loss of appetite
  • Headache
  • Feeling dizzy or tired
  • Changes in taste

Rare but serious: get medical help

  • Signs of a severe allergic reaction: swelling of the face, lips or throat, difficulty breathing, or collapse. Call 112 or go to hospital straight away
  • A serious skin reaction: a widespread rash with blisters or peeling skin, sores in the mouth, or a rash with fever and swollen glands
  • A fast, pounding or irregular heartbeat, or fainting, which can be a sign of a heart rhythm problem
  • Yellowing of the skin or eyes, dark urine, pale stools or severe tiredness, which can be signs of liver problems
  • Severe or watery diarrhoea that does not stop, or diarrhoea with blood or mucus, which can be a sign of a gut infection called C. difficile. This can start up to 2 months after the course
  • Ringing in the ears, hearing loss or a spinning feeling (vertigo)
  • New or worse muscle weakness, drooping eyelids or difficulty swallowing or breathing in people with myasthenia gravis
  • In babies a few weeks old: forceful vomiting or irritability when feeding. Contact a doctor straight away

Who should be careful

Azithromycin is not suitable for everyone. Tell your doctor about your health conditions and other medicines before taking it.

When the label says not to use it

  • Allergy to azithromycin, erythromycin or any other macrolide or ketolide antibiotic
  • Past jaundice or liver damage that happened while taking azithromycin
  • It treats bacterial infections only. It does not work for colds, flu, most coughs or other viral infections, and using it when it is not needed adds to antibiotic resistance
  • Past allergic reaction to azithromycin or other macrolide antibiotics such as erythromycin or clarithromycin
  • Heart rhythm problems, a known long QT interval, a slow heart rate, heart failure, or low potassium or magnesium: azithromycin can rarely cause a dangerous irregular heartbeat
  • Liver disease, or past liver problems after taking azithromycin
  • Severe kidney disease
  • Myasthenia gravis: azithromycin can make muscle weakness worse
  • Past diarrhoea while taking antibiotics
  • Pregnancy: azithromycin can be used when an infection needs treatment, but your doctor will decide whether it is the right antibiotic
  • Breastfeeding: small amounts pass into breast milk. Watch the baby for diarrhoea, vomiting, rash or thrush, and tell your doctor if you notice them
  • Dizziness: do not drive or use machines if azithromycin makes you dizzy

Medicines and things that interact with Azithromycin

Azithromycin has a few important interactions. Tell your doctor or pharmacist about every medicine you take, including herbal products.

  • Antacids containing aluminium or magnesium: do not take them at the same time as azithromycin; keep a gap as the label or pharmacist advises
  • Medicines that can affect heart rhythm, such as amiodarone, sotalol, citalopram, some antipsychotics, domperidone, hydroxychloroquine and moxifloxacin: a higher risk of an irregular heartbeat
  • Warfarin and other blood thinners: their effect may increase, so your doctor may check your clotting more often
  • Digoxin and colchicine: their levels in the blood may rise
  • Ciclosporin and tacrolimus (medicines that suppress the immune system): levels may need checking
  • Ergotamine or dihydroergotamine (migraine medicines): should not be taken with azithromycin
  • Statins such as simvastatin and atorvastatin: tell your doctor about any unexplained muscle pain

If someone takes too much

Taking too much azithromycin mainly causes stronger side effects, such as nausea, vomiting and diarrhoea, and there is no specific antidote. One extra dose taken by mistake is unlikely to cause serious harm. If someone has taken much more than prescribed, or feels unwell, call 112 or go to the nearest hospital and take the medicine pack with you.

In India

Price cap, essential-medicine listing and legal status in India, taken from government notifications.

Price cap (NPPA)

  • 250 mg tablet₹11.95 per tablet
  • 500 mg tablet₹24.14 per tablet
  • 1000 mg tablet₹59.17 per tablet
  • 200 mg/5 mL oral liquid₹3.49 per mL

Ceiling price fixed by the National Pharmaceutical Pricing Authority (NPPA), excluding GST, in force from 1 April 2026 (S.O. 1575(E) dated 25 March 2026). The printed pack price (MRP) may not be higher than this price plus GST.

Essential medicine (NLEM)

Listed in the National List of Essential Medicines (NLEM) 2022: 250 mg tablet, 500 mg tablet, 1000 mg tablet, 200 mg/5 mL oral liquid, 500 mg injection.

Regulatory status in India

Approved for sale in India. Azithromycin is a prescription antibiotic. Single-ingredient azithromycin is not on the CDSCO list of banned medicines. Several fixed-dose combinations that pair azithromycin with other ingredients are prohibited, for example azithromycin with cefixime, ofloxacin, levofloxacin or ambroxol (2018) and with adapalene (2024), so check the ingredient list on the pack.

Type of medicine

Azithromycin belongs to this type of medicine.

Medicines that contain Azithromycin

These medicines sold in India contain Azithromycin. They are listed A to Z, not ranked.

What is Azithromycin used for?

Medicines that contain Azithromycin are used for these conditions.

Common questions

How long does an azithromycin course last?

Courses are often short, commonly 3 to 5 days, and some infections are treated with a single larger dose. Because azithromycin leaves the body slowly, its effect continues for several days after the last dose. Your doctor decides the dose and length; take the full course as prescribed.

Should azithromycin be taken with food?

Advice differs: the US label says the tablets can be taken with or without food, while the NHS advises taking them 1 hour before or 2 hours after a meal. Follow the instructions on your pack or your doctor's advice, and keep antacids apart from the dose.

Is Azithral 500 the same as azithromycin?

Azithral 500 is a brand name. Its tablet contains azithromycin alone, 500 mg per tablet, so the medicine is azithromycin. Other brands also sell azithromycin in different strengths, and some may add other ingredients, so check the ingredient list and strength on the pack.

Does azithromycin work for a cold, flu or COVID-19?

No. Azithromycin works only against bacteria, so it does not treat colds, flu, COVID-19 or other viral infections. A doctor decides whether an infection is bacterial. Using antibiotics when they are not needed adds to antibiotic resistance.

Can I drink alcohol while taking azithromycin?

There is no known direct interaction between alcohol and azithromycin. Alcohol can add to dizziness or an upset stomach, which are possible side effects, and being unwell is a reason to take care. Ask your doctor or pharmacist if you are unsure.

Can I take azithromycin in pregnancy or while breastfeeding?

Azithromycin can be used in pregnancy and breastfeeding when an infection needs treatment, but only a doctor should decide this. Small amounts pass into breast milk, so tell your doctor if the baby has diarrhoea, vomiting, a rash or thrush.

What is the difference between azithromycin and amoxicillin?

Both are antibiotics for bacterial infections but belong to different families: azithromycin is a macrolide and amoxicillin is a penicillin. They act on bacteria differently and suit different infections. A doctor chooses between them, and penicillin allergy matters when choosing.

Should I stop azithromycin when I feel better?

Follow the course your doctor prescribed, for as many days as advised. Because azithromycin stays in the body for several days, a short course can still be a complete one. Do not keep leftover tablets for another illness; tell your doctor if you feel worse.

Can azithromycin be taken with paracetamol or Dolo 650?

Neither the azithromycin label nor NHS guidance lists an interaction with paracetamol. They do different jobs: paracetamol eases fever or pain, while azithromycin treats a bacterial infection. Keep paracetamol within its daily limit from all products combined, and follow each medicine's own instructions.

Can azithromycin cause diarrhoea or loose motions?

Yes. Antibiotics upset the normal bacteria in the gut, so loose motions are a common side effect. Drink plenty of fluids. Get medical help quickly if diarrhoea is severe, watery or does not stop, or contains blood or mucus, even weeks after the course. Ask a doctor before taking anti-diarrhoea medicine.

Is azithromycin used for typhoid?

Doctors in India may prescribe azithromycin for typhoid (enteric fever). The ICMR antibiotic treatment guidelines include it, partly because typhoid bacteria are often resistant to older medicines. Typhoid needs a doctor's diagnosis, usually with a blood test. Fever has many causes, including dengue and malaria, which antibiotics do not treat.

Does azithromycin work for a sore throat or throat infection?

Most sore throats are caused by viruses and get better on their own, so an antibiotic does not help them. When a bacterial infection such as strep throat is likely, a doctor may prescribe an antibiotic; azithromycin is one option, mainly for people who cannot take penicillin-type antibiotics.

Can azithromycin affect the liver or kidneys?

Serious liver problems are rare but have been reported. Get medical help urgently if you notice yellow skin or eyes, dark urine, pale stools, or severe tiredness or stomach pain. Tell your doctor beforehand about any liver or kidney disease, because azithromycin is used with caution when either is severe.

Can children take azithromycin?

Yes, when a doctor prescribes it, usually as a syrup (oral suspension). A child's dose depends on body weight, so give only the dose the doctor sets and measure it with the syringe or cup supplied, not a kitchen spoon. Do not give a child adult tablets unless the doctor says so.

How long does azithromycin take to work?

For most infections, people start to feel better within a few days, according to NHS guidance. Keep taking it for as long as prescribed, even after you feel better. If you are not improving after a few days, feel worse or get new symptoms, see your doctor, as the infection may need a different medicine.

Are Azithral 500, Azee 500 and other azithromycin 500 brands the same?

Each contains 500 mg of azithromycin per tablet, so the medicine and strength are the same. Brands differ in maker, price, inactive ingredients and tablet appearance. Check the ingredient list and strength on the pack, since some products add other medicines, and ask a pharmacist if you are unsure.

Sources

  1. ZITHROMAX (azithromycin) tablets and oral suspension: full prescribing information. Pfizer, US FDA-approved labeling
  2. Azithromycin. StatPearls, National Center for Biotechnology Information (NCBI), US National Library of Medicine
  3. Azithromycin: an antibiotic to treat bacterial infections. NHS (UK)
  4. How and when to take azithromycin. NHS (UK)
  5. National Formulary of India. Indian Pharmacopoeia Commission
  6. Treatment Guidelines for Antimicrobial Use in Common Syndromes (2nd edition, 2019). Indian Council of Medical Research (ICMR)
  7. Sore throat. NHS (UK)
  8. S.O. 1575(E), 25 March 2026: revision of ceiling prices of 767 scheduled formulations under NLEM 2022 (annual WPI revision). National Pharmaceutical Pricing Authority (NPPA), Government of India
  9. National List of Essential Medicines 2022 (sections 6.2.2.1 and 6.7.6.1, Azithromycin). Ministry of Health and Family Welfare, Government of India (copy hosted by CDSCO)